Quarterfinals
The Quarterfinals were played on May 14, 15, and May 21 and 22. Team #1 played the second leg at home.
| Team #1 | Points | Team #2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Fluminense | (gd) 3–3 | São Paulo | 0–1 | 3–1 |
| Santos | 3–3 (gd) | América | 0–2 | 1–0 |
| LDU Quito | 2–2 (5–3 p) | San Lorenzo | 1–1 | 1–1 |
| Atlas | 1–4 | Boca Juniors | 2–2 | 0–3 |
Read more about this topic: 2008 Copa Libertadores Knockout Stages