Schedule
| Date | Time | Opponent# | Rank# | Site | TV | Result | Attendance | |
|---|---|---|---|---|---|---|---|---|
| September 2 | 6:30 PM | Western Illinois* | Faurot Field • Columbia, MO | W 50–20 | 53,224 | |||
| September 9 | 2:30 PM | at #17 Clemson* | Memorial Stadium • Clemson, SC | ABC | L 9–62 | 70,382 | ||
| September 16 | 6:00 PM | Michigan State* | Faurot Field • Columbia, MO | FSN | L 10–13 | 55,289 | ||
| September 30 | 6:00 PM | at #1 Nebraska | Memorial Stadium • Lincoln, NE (Rivalry) | FSN | L 24–42 | 77,744 | ||
| October 7 | 1:00 PM | Oklahoma State | Faurot Field • Columbia, MO | W 24–10 | 51,149 | |||
| October 14 | 1:00 PM | Kansas | Faurot Field • Columbia, MO (Border War) | L 17–38 | 61,794 | |||
| October 21 | 1:30 PM | at Texas | Darrell K Royal–Texas Memorial Stadium • Austin, TX | L 12–46 | 82,892 | |||
| October 28 | 6:00 PM | at Iowa State | Jack Trice Stadium • Ames, IA (Telephone Trophy) | FSN | L 20–39 | 46,599 | ||
| November 4 | 1:00 PM | Colorado | Faurot Field • Columbia, MO | L 18–28 | 50,567 | |||
| November 11 | 1:00 PM | at Baylor | Floyd Casey Stadium • Waco, TX | W 47–22 | 29,872 | |||
| November 18 | 11:30 AM | #9 Kansas State | Faurot Field • Columbia, MO | FSN | L 24–28 | 49,277 | ||
Read more about this topic: 2000 Missouri Tigers Football Team