Schedule
| Date | Opponent | Location | Result | Score | Record | Attendance |
|---|---|---|---|---|---|---|
| Sunday, Oct. 2 | Waukegan Legion | Staley Field | Win | 35-0 | 0-0-0 | |
| Monday, Oct. 10 | Rock Island Independents | Staley Field | Win | 14-10 | 1-0-0 | 5,000 |
| Sunday, Oct. 16 | Rochester Jeffersons | Cubs Park | Win | 16-13 | 2-0-0 | 8,000 |
| Sunday, Oct. 23 | Dayton Triangles | Cubs Park | Win | 7-0 | 3-0-0 | 8,000 |
| Sunday, Nov. 6 | Detroit Tigers | Cubs Park | Win | 20-9 | 4-0-0 | 6,000 |
| Sunday, Nov. 13 | Rock Island Independents | Cubs Park | Win | 3-0 | 5-0-0 | 4,000 |
| Sunday, Nov. 20 | Cleveland Indians | Cubs Park | Win | 22-7 | 6-0-0 | 10,000 |
| Thursday, Nov. 24 | Buffalo All-Americans | Cubs Park | Loss | 6-7 | 6-1-0 | |
| Sunday, Nov. 27 | Green Bay Packers | Cubs Park | Win | 20-0 | 7-1-0 | 7,000 |
| Sunday, Dec. 4 | Buffalo All-Americans | Cubs Park | Win | 10-7 | 8-1-0 | 12,000 |
| Sunday, Dec. 11 | Canton Bulldogs | Cubs Park | Win | 10-0 | 9-1-0 | 3,000 |
| Sunday, Dec. 18 | Chicago Cardinals | Cubs Park | Tie | 0-0 | 9-1-1 | 2,000 |
- Game in italics was against a non-league opponent
Read more about this topic: 1921 Chicago Staleys Season