In computer architecture, 128-bit integers, memory addresses, or other data units are those that are at most 128 bits (16 octets) wide. Also, 128-bit CPU and ALU architectures are those that are based on registers, address buses, or data buses of that size.
While there are currently no mainstream general-purpose processors built to operate on 128-bit integers or addresses, a number of processors do have specialized ways to operate on 128-bit chunks of data. The IBM System/370 could be considered the first rudimentary 128-bit computer, as it used 128-bit floating point registers. Most modern CPUs feature SIMD instruction sets (SSE, AltiVec etc.) where 128-bit vector registers are used to store several smaller numbers, such as four 32-bit floating-point numbers. A single instruction can then operate on all these values in parallel. However, these processors do not operate on individual numbers that are 128 binary digits in length, only their registers have the size of 128-bits.
The DEC VAX supported operations on 128-bit integer ('O' or octaword) and 128-bit floating-point ('H-float' or HFLOAT) datatypes. Support for such operations was an upgrade option rather than being a standard feature. Since the VAX's registers were 32 bits wide, a 128-bit operation used four consecutive registers or four longwords in memory.