Isoforms
In humans, there are two HSD11B isoforms:
| HSD11B1 | NADPH-dependent | Highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. | In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. |
| HSD11B2 | NAD+-dependent | Expressed in aldosterone-selective tissues, including kidneys, colon, salivary glands, and placenta. | In these tissues, HSD11B2 oxidizes cortisol to cortisone and prevents illicit activation of the mineralocorticoid receptor. |
Inhibition of HSD11B1 has been suggested as a possible therapy for treatment of obesity and metabolic syndrome.
Read more about this topic: 11-Beta Hydroxysteroid Dehydrogenase
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