Zook can refer to the following:
People:
- Chris Zook, business writer
- Frederic Zook, President of Ottawa University and former mayor of Ottawa, Kansas
- George F. Zook (1885-1951), American educator
- R. Harold Zook (1889-1949), American architect
- John Zook (born 1947), National Football League player
- Ron Zook (born 1954), former head football coach at the University of Illinois
- Samuel K. Zook (1821-1863), Union army general killed at Gettysburg
Places:
- Zook, Kansas, Pawnee County, Kansas
- 14267 Zook, an asteroid
In entertainment:
- a creature designed by a contestant on the BBC game show Bamzooki
- Zook (comics), a DC Comics alien associated with the Martian Manhunter
- Zook, someone who eats their bread butter side down in Dr. Seuss's The Butter Battle Book
- Zook (band), a Finnish rock band