Zap70

ZAP70

Identifiers Symbols ZAP70; SRK; STCD; STD; TZK; ZAP-70 External IDs OMIM: 176947 MGI: 99613 HomoloGene: 839 ChEMBL: 2803 GeneCards: ZAP70 Gene EC number 2.7.10.2

Gene Ontology
Molecular function	• phosphotyrosine binding • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • protein binding • ATP binding
Cellular component	• immunological synapse • cytoplasm • cytosol • plasma membrane • T cell receptor complex
Biological process	• adaptive immune response • protein phosphorylation • immune response • intracellular protein kinase cascade • peptidyl-tyrosine phosphorylation • T cell differentiation • T cell activation • B cell activation • beta selection • positive thymic T cell selection • negative thymic T cell selection • positive regulation of T cell differentiation • positive regulation of alpha-beta T cell differentiation • positive regulation of alpha-beta T cell proliferation • protein autophosphorylation • positive regulation of calcium-mediated signaling • T cell receptor signaling pathway • T cell aggregation • T cell migration
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7535 22637 Ensembl ENSG00000115085 ENSMUSG00000026117 UniProt P43403 P43404 RefSeq (mRNA) NM_001079.3 NM_009539.2 RefSeq (protein) NP_001070.2 NP_033565.2 Location (UCSC) Chr 2:
98.33 – 98.36 Mb Chr 1:
36.76 – 36.78 Mb PubMed search

ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of T cells and natural killer cells. It is part of the T cell receptor, and plays a critical role in T-cell signaling. Its molecular weight is 70 kDa, and it is a member of the protein-tyrosine kinase family.