WSC is an abbreviation that may stand for:
- Wall Street Crash
- Warwick Student Cinema, the film society of the University of Warwick
- Washington Sports Clubs, division of New York City-based TSI Holdings
- Wayne State College
- Weight-shift control aircraft
- Weinheimer Senioren-Convent, German student association
- Werribee Secondary College, Australian high school in Werribee, Victoria
- Wesco Financial, financial corporation whose stock symbol is WSC
- West Shore Conference, high school athletics conference in Ohio
- Westside Connection
- West Spitsbergen Current, an ocean current
- Western Springs College
- Westminster Seminary California
- Westminster Shorter Catechism
- When Saturday Comes, football magazine
- When Saturday Comes (film), British football film
- White Sands Complex, TDRS center and missile range
- Wiener Sportclub, an athletics club in Vienna
- Wild Salmon Center
- Windows Security Center, a component of Windows XP, Windows Vista, and Windows 7
- Winston Spencer Churchill, Prime Minister of the United Kingdom 1940–45 and 1951–55
- WonderSwan Color, a handheld video game system
- Worcester State College
- World Scholar's Cup
- World Scout Conference
- World Scrabble Championship
- World Series Cricket
- World Shipping Council, an industry group
- World Shooting Championships
- World Ski Championships (disambiguation)
- World Snooker Championship
- World Solar Challenge
- World Sportscar Championship
- World Sports Car, a prototype class in the IMSA GT Championship
- World Standards Cooperation, an alliance of the IEC, ISO and ITU international standardization organizations
- World Sudoku Championship