Wasco is the name of four places in the United States:
- Wasco, California, a city in California
- Wasco State Prison, located in Wasco, California
- Wasco, Illinois, a former hamlet (unincorporated town) in Illinois, now part of Campton Hills
- Wasco, Oregon, a city in Oregon
- Wasco County, Oregon, a county in Oregon
Wasco may also mean:
- Wasco-Wishram, two Native American tribes from Oregon
- Wasco-Wishram language, a dialect of Upper Chinook, a Chinookan language