Structure
Vinculin is a 117-kDa cytoskeletal protein with 1066 amino acids. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. Vinculin consists of a globular head domain that contains binding sites for talin and α-actinin as well as a tyrosine phosphorylation site, while the tail region contains binding sites for F-actin, paxillin, and lipids (Goldman et al. 2001).
Essentially, there is a 835 amino acid N-terminal head, which is split into four domains. This is linked to the C-terminal head with a linker region.
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