Upshaw is a surname of English origin. Notable people with this name include:
- Cecil Upshaw (1942–1995), American baseball player
- Courtney Upshaw (born 1989), American football player
- Dawn Upshaw (born 1960), American operatic and classical soprano
- Gene Upshaw (1945–2008), American football player
- Grace Upshaw (born 1975), American Olympic track and field athlete
- Jessica Upshaw (1959–2013), American politician and lawyer
- Kelvin Upshaw (born 1963), American basketball player
- L. W. Upshaw, American college football coach
- Marvin Upshaw (born 1946), American football player
- Orrin Upshaw (1874–1937), American Olympic tug-of-war athlete
- Regan Upshaw (born 1975), American football player
- T. D. Upshaw (fl. 1930–1931), American college football coach
- William D. Upshaw (1866–1952), American prohibitionist and politician from Georgia; U.S. representative 1919–27
- Willie Upshaw (born 1957), American baseball player
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