Twitchell is a surname, and may refer to
- David and Ginger Twitchell, Christian Scientists who were tried for manslaughter in the death of their son, Robyn
- Rev. Dr. Joseph Twichell, A New England reverend, and closest friend of Mark Twain
- Karl Twitchell, American engineer and surveyor
- Kent Twitchell, American artist
- Mark Twitchell, Canadian filmmaker charged with murder
- Marshall H. Twitchell, Louisiana state senator and carpetbagger during Reconstruction
- Paul Twitchell, American religious leader
- Wayne Twitchell, American baseball player
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