Testin - Domain Organisation

Domain Organisation

Tes is composed of the following domains:

Domain Name Boundaries Domain type
Cysteine rich domain 1 - 90 No Homology
PET domain 90 - 200 PET domain - no structure
Linker . 201 - 233 no domain
LIM1 234 - 300 LIM domain
LIM2 300 - 365 LIM domain
LIM3 366 - 421 LIM domain

The structures of the Cysteine rich domain and the PET domain are not known. LIM domains, however, are known as modulators of protein interactions. LIM domain consist of 2 zinc fingers separated by 2 hydrophobic amino acids (generally a phenylalanine and then a leucine).

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