Testin

Testin

Identifiers Symbols TES; TESS; TESS-2 External IDs OMIM: 606085 MGI: 105081 HomoloGene: 41051 GeneCards: TES Gene

Gene Ontology
Molecular function • zinc ion binding
Cellular component • cytoplasm
• plasma membrane
• focal adhesion
• cell junction
• protein complex
Biological process • negative regulation of cell proliferation
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26136 21753 Ensembl ENSG00000135269 ENSMUSG00000029552 UniProt Q9UGI8 P47226 RefSeq (mRNA) NM_015641 NM_011570 RefSeq (protein) NP_056456 NP_997059 Location (UCSC) Chr 7:
115.85 – 115.9 Mb Chr 6:
17.07 – 17.11 Mb PubMed search


Testin also known as TESS is a protein that in humans is encoded by the TES gene located on chromosome 7. TES is a 47 kDa protein composed of 421 amino acids found at focal adhesions and is thought to have a role in regulation of cell motility. In addition to this, TES functions as a tumour suppressor. The TES gene is located within a fragile region of chromosome 7, and the promoter elements of the TES gene have been shown to be susceptible to methylation - this prevents the expression of the TES protein. TES came to greater prominence towards the end of 2007 as a potential mechanism for its tumour suppressor function was published.

Read more about Testin:  Domain Organisation, Binding Partners, TES As A Tumour Suppressor, Conformational Change, Phenotype