Deficiency
Naked mole rats lack cutaneous C fibers reactive to substance P (SP) and many small neurons that are normally SP-positive. Thus, these animals are insensitive to pain when painful stimuli are administered to the skin. New studies have shown that when the function of SP is genetically disrupted in mice, the animals demonstrated reduced responses to painful stimuli. Moreover, the response to capsaicin was absent or severely reduced in knockout mice.
Read more about this topic: Substance P
Famous quotes containing the word deficiency:
“All rejection and negation indicates a deficiency in fertility: fundamentally, if only we were good plowland we would allow nothing to go unused, and in every thing, event, and person we would welcome manure, rain, or sunshine.”
—Friedrich Nietzsche (1844–1900)
“It is easier to discover a deficiency in individuals, in states, and in Providence, than to see their real import and value.”
—Georg Wilhelm Friedrich Hegel (1770–1831)
“If a man is a good lawyer, a good physician, a good engineer ... he may be a fool in every other capacity. But no deficiency or mistake of judgment is forgiven to a woman ... and should she fail anywhere, if she has any scientific attainment, or artistic faculty, instead of standing her interest as an excuse, it is censured as an aggravation and offence.”
—E.P.P., U.S. women’s magazine contributor. The Una, p. 28 ( February 1855)