Substance P

In the field of neuroscience, substance P (SP) is a neuropeptide: an undecapeptide that functions as a neurotransmitter and as a neuromodulator. It belongs to the tachykinin neuropeptide family. Substance P and its closely related neuropeptide neurokinin A (NKA) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene. The deduced amino acid sequence of substance P is as follows:

  • Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met

with an amidation at the C-terminus. Substance P is released from the terminals of specific sensory nerves, it is found in the brain and spinal cord, and is associated with inflammatory processes and pain.

Read more about Substance P:  Discovery, Receptor, Function, Deficiency

Other articles related to "substance p":

Substance P - Deficiency
... Naked mole rats lack cutaneous C fibers reactive to substance P (SP) and many small neurons that are normally SP-positive ...

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