In the field of neuroscience, substance P (SP) is a neuropeptide: an undecapeptide that functions as a neurotransmitter and as a neuromodulator. It belongs to the tachykinin neuropeptide family. Substance P and its closely related neuropeptide neurokinin A (NKA) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene. The deduced amino acid sequence of substance P is as follows:
- Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met
with an amidation at the C-terminus. Substance P is released from the terminals of specific sensory nerves, it is found in the brain and spinal cord, and is associated with inflammatory processes and pain.
Other articles related to "substance p":
... rats lack cutaneous C fibers reactive to substance P (SP) and many small neurons that are normally SP-positive ...
Famous quotes containing the word substance:
“What makes literature interesting is that it does not survive its translation. The characters in a novel are made out of the sentences. Thats what their substance is.”
—Jonathan Miller (b. 1936)