In the field of neuroscience, substance P (SP) is a neuropeptide: an undecapeptide that functions as a neurotransmitter and as a neuromodulator. It belongs to the tachykinin neuropeptide family. Substance P and its closely related neuropeptide neurokinin A (NKA) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene. The deduced amino acid sequence of substance P is as follows:
- Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met
with an amidation at the C-terminus. Substance P is released from the terminals of specific sensory nerves, it is found in the brain and spinal cord, and is associated with inflammatory processes and pain.
Read more about Substance P: Discovery, Receptor, Function, Deficiency
Other articles related to "substance p":
... Naked mole rats lack cutaneous C fibers reactive to substance P (SP) and many small neurons that are normally SP-positive ...
Famous quotes containing the word substance:
“What is a country without rabbits and partridges? They are among the most simple and indigenous animal products; ancient and venerable families known to antiquity as to modern times; of the very hue and substance of Nature, nearest allied to leaves and to the ground,—and to one another; it is either winged or it is legged. It is hardly as if you had seen a wild creature when a rabbit or a partridge bursts away, only a natural one, as much to be expected as rustling leaves.”
—Henry David Thoreau (1817–1862)