Souther may refer to:
- Souther (meteorology), a strong wind coming from the south
- Souther, an antagonist in the manga/anime series Fist of the North Star
- J. D. Souther, an American singer and songwriter
- Souther Field, Americus, Georgia Airport
- Richard Souther, an American composer and instrumentalist
- John Souther (1816 – 1911), founder of Globe Locomotive Works
- Michael Souther, a Canadian television director, producer and writer
- Calvin Souther Fuller (1902 – 1994), an American physical chemist and co-inventor of the solar cell
- Souther Fell, a mountainous landscape in the English Lake District
- Souther-Hillman-Furay Band, a country rock group with Richie Furay, Chris Hillman, and J.D. Souther
- John Souther House, an historic house in Newton, Massachusetts, United States
- Millard-Souther-Green House, an historic house in Stoneham, Massachusetts, United States
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