Sixer or Sixers may refer to:
- Philadelphia 76ers, a professional basketball team in Philadelphia, Pennsylvania, United States
- Sixer, a punk band from Richmond, Virginia, United States
- Fort Worth Sixers, a National Indoor Football League franchise in the United States
- Sydney Sixers, an Australian cricket franchise
- Southern Sixers, mountains in the southern United States which are at least six thousand feet tall
- Stephen Kellogg and the Sixers, an American rock band
- The members of the sixth pilgrimage to Terra Nova, the settlement in the U.S. TV series of the same name