Technology
The DNA sequencing is done on a chip that contains many ZMWs. Inside each ZMW, a single active DNA polymerase with a single molecule of single stranded DNA template is immobilized to the bottom through which light can penetrate and create a visualization chamber that allows monitoring of the activity of the DNA polymerase at a single molecule level. The signal from a phospho-linked nucleotide incorporated by the DNA polymerase is detected as the DNA synthesis proceeds which results in the DNA sequencing in real time.
Read more about this topic: Single Molecule Real Time Sequencing
Famous quotes containing the word technology:
“One can prove or refute anything at all with words. Soon people will perfect language technology to such an extent that they’ll be proving with mathematical precision that twice two is seven.”
—Anton Pavlovich Chekhov (1860–1904)
“Our technology forces us to live mythically, but we continue to think fragmentarily, and on single, separate planes.”
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“The successor to politics will be propaganda. Propaganda, not in the sense of a message or ideology, but as the impact of the whole technology of the times.”
—Marshall McLuhan (1911–1980)