Simone may refer to:
- S1m0ne, a 2002 science fiction drama film
- Simone (actress), the stage name of Lisa Celeste Stroud, daughter of Nina Simone
- Simone (character), a fictional character in the ABC Family show The Nine Lives of Chloe King
- Simone (given name), a feminine (or masculine, in Italian) given name of Hebrew origin
- Simone (surname), a surname
- Simone (singer), a Danish singer
- Simone Bittencourt de Oliveira, a Brazilian singer and performer
- Tropical Storm Simone (disambiguation), two tropical cyclones in the Eastern Pacific Ocean