Septal Nuclei

The septal nuclei (medial olfactory area) are a set of structures that lie below the rostrum of the corpus callosum, anterior to the lamina terminalis (the layer of gray matter in the brain connecting the optic chiasma and the anterior commissure where the latter becomes continuous with the rostral lamina). The septal nuclei are composed of medium-size neurons which are classified into medial, lateral, and posterior groups. The septal nuclei receive reciprocal connections from the olfactory bulb, hippocampus, amygdala, hypothalamus, midbrain, habenula, cingulate gyrus, and thalamus. The septal area (medial olfactory area) has no relation to the smell, but it is considered a pleasure zone in animals. The septal nuclei play a role in reward and reinforcement along with the nucleus accumbens. In the 1950s, Olds & Milner showed that rats with electrodes implanted in this area will self-stimulate repeatedly (i.e. press a bar to receive electrical current that will stimulate the neurons).