Roxbury may refer to:
- United States
- Roxbury, Boston, Massachusetts
- Roxbury, Connecticut
- Roxbury, Kansas
- Roxbury, Maine
- Roxbury, New Hampshire
- Roxbury Township, New Jersey
- Roxbury, New York (in Delaware County)
- Roxbury, Queens, New York, part of the Rockaway Peninsula
- Roxbury, Pennsylvania
- Roxbury, Vermont
- Roxbury (Oak Grove, Virginia), listed on the NRHP in Virginia
- Roxbury, Wisconsin, a town
- Roxbury (community), Wisconsin, an unincorporated community
- Wirtland, Virginia a part of Oak Grove, Virginia