RELA

RELA

Identifiers Symbols RELA; NFKB3; p65 External IDs OMIM: 164014 MGI: 103290 HomoloGene: 32064 ChEMBL: 5533 GeneCards: RELA Gene

Gene Ontology
Molecular function	• DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • protein binding • transcription factor binding • protein kinase binding • ubiquitin protein ligase binding • protein complex binding • activating transcription factor binding • phosphate ion binding • identical protein binding • sequence-specific DNA binding • transcription regulatory region DNA binding • protein N-terminus binding • NF-kappaB binding • repressing transcription factor binding • ankyrin repeat binding
Cellular component	• nucleus • nucleoplasm • transcription factor complex • cytoplasm • cytosol
Biological process	• liver development • hair follicle development • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • acetaldehyde metabolic process • inflammatory response • cellular defense response • aging • positive regulation of cell proliferation • response to mechanical stimulus • organ morphogenesis • response to organic substance • response to UV-B • positive regulation of Schwann cell differentiation • virus-host interaction • cytokine-mediated signaling pathway • membrane protein intracellular domain proteolysis • positive regulation of chondrocyte differentiation • positive regulation of type I interferon production • response to muramyl dipeptide • response to progesterone stimulus • response to insulin stimulus • response to cobalamin • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • negative regulation of protein catabolic process • response to drug • response to hydrogen peroxide • negative regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB cascade • response to amino acid stimulus • response to morphine • positive regulation of interleukin-12 biosynthetic process • innate immune response • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • negative regulation of insulin receptor signaling pathway • neurotrophin TRK receptor signaling pathway • regulation of inflammatory response • T cell receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • response to cAMP • defense response to virus • nucleotide-binding oligomerization domain containing 2 signaling pathway • response to interleukin-1 • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to tumor necrosis factor
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5970 19697 Ensembl ENSG00000173039 ENSMUSG00000024927 UniProt Q04206 Q04207 RefSeq (mRNA) NM_001145138 NM_009045 RefSeq (protein) NP_001138610 NP_033071 Location (UCSC) Chr 11:
65.42 – 65.43 Mb Chr 19:
5.64 – 5.65 Mb PubMed search

Transcription factor p65 is a protein that in humans is encoded by the RELA gene.