Medical Conditions Related To Purkinje Cells
In humans, Purkinje cells are affected in a variety of diseases ranging from toxic exposure (alcohol, lithium), to autoimmune diseases and to genetic mutations (spinocerebellar ataxias, Unverricht-Lundborg disease, autism) and neurodegenerative diseases that are not thought to have a known genetic basis (cerebellar type of multiple system atrophy, sporadic ataxias).
In some domestic animals, a condition where the Purkinje cells begin to atrophy shortly after birth, called Cerebellar abiotrophy, can lead to symptoms including ataxia, intention tremors, hyperreactivity, lack of menace reflex, stiff or high-stepping gait, apparent lack of awareness of wherein the feet are (sometimes standing or walking with a foot knuckled over), and a general inability to determine space and distance. A similar condition known as cerebellar hypoplasia occurs when Purkinje cells either fail to develop in utero or die off in utero prior to birth. The genetic conditions Ataxia Telangiectasia and Niemann Pick disease Type C, as well as cerebellar essential tremor, involve the progressive loss of Purkinje cells. Spinal pathology as well as loss of dendritic branches of the Purkinje cells have been also described in Alzheimer's disease. Purkinje cells can also be damaged by the Rabies virus as it migrates from the site of infection in the periphery to the central nervous system
Read more about this topic: Purkinje Cell
Famous quotes containing the words medical, conditions, related and/or cells:
“Unusual precocity in children, is usually the result of an unhealthy state of the brain; and, in such cases, medical men would now direct, that the wonderful child should be deprived of all books and study, and turned to play or work in the fresh air.”
—Catherine E. Beecher (1800–1878)
“It is part of the educator’s responsibility to see equally to two things: First, that the problem grows out of the conditions of the experience being had in the present, and that it is within the range of the capacity of students; and, secondly, that it is such that it arouses in the learner an active quest for information and for production of new ideas. The new facts and new ideas thus obtained become the ground for further experiences in which new problems are presented.”
—John Dewey (1859–1952)
“A parent who from his own childhood experience is convinced of the value of fairy tales will have no difficulty in answering his child’s questions; but an adult who thinks these tales are only a bunch of lies had better not try telling them; he won’t be able to related them in a way which would enrich the child’s life.”
—Bruno Bettelheim (20th century)
“They are sworn enemies of lyric poetry.
In prison they accompany the jailer,
Enter cells to hear confessions.
Their short-end comes down
When you least expect it.”
—Charles Simic (b. 1938)