Puffy can refer to one of the following:
- Puffy or Puffy AmiYumi (as they are known in the United States), a Japanese pop duo
- Hi Hi Puffy AmiYumi, animation series about fictional adventures of Puffy AmiYumi
- Puffy: P.S. I Love You, 1999 PlayStation game featuring Puffy AmiYumi
- Puffy de Rumba, a single by Puffy AmiYumi
- Puffy, a nickname of Sean Combs, American record producer, music industry executive, and part-time performing artist
- Puffy (mascot), the mascot of the free operating system OpenBSD
- Puffy, a nickname of Mike Bordin, an American drummer from the rock band Faith No More
- Puffy, a nickname of Jeff Dubay, a Minnesota sports talk radio personality on the radio station, KFAN
- Puffy planet, a class of gas giant planets that have a low density