Formation and Degradation
Besides de novo synthesis, PA can be formed in three ways:
- By phospholipase D (PLD), via the hydrolysis of the P-O bond of phosphatidylcholine (PC) to produce PA and choline.
- By the phosphorylation of diacylglycerol (DAG) by DAG kinase (DAGK)
- By the acylation of lysophosphatidic acid by lysoPA-acyltransferase (LPAAT); this is the most common pathway.
PA is degraded by conversion into DAG by lipid phosphate phosphohydrolases (LPPs) or into lyso-PA by phospholipase A (PLA).
Read more about this topic: Phosphatidic Acid
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