Pacelli is an Italian surname.
- Asprilio Pacelli (1570–1623), Italian Baroque composer
- Ernesto Pacelli (d. 1925), Vatican financial adviser, cousin of Pius XII
- Eugenio Pacelli (1876–1958), Pope Pius XII
- Francesco Pacelli (1872–1935), Vatican lawyer, elder brother of Pius XII
- Frank Pacelli (1934–1999), American TV personality
- Vincent "Vinny Basile" Pacelli, American Mafioso indicted in Operation Old Bridge