OGT (gene)

OGT (gene)

Identifiers Symbols OGT; HRNT1; O-GLCNAC External IDs OMIM: 300255 MGI: 1339639 HomoloGene: 9675 ChEMBL: 5955 GeneCards: OGT Gene EC number 2.4.1.255

Gene Ontology
Molecular function	• protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • enzyme activator activity • acetylglucosaminyltransferase activity • protein N-acetylglucosaminyltransferase activity • histone acetyltransferase activity (H4-K5 specific) • histone acetyltransferase activity (H4-K8 specific) • histone acetyltransferase activity (H4-K16 specific)
Cellular component	• histone acetyltransferase complex • nucleus • nucleolus • mitochondrion • centrosome • cytosol • plasma membrane • MLL5-L complex
Biological process	• regulation of glycolysis • protein O-linked glycosylation • apoptotic process • induction of apoptosis • signal transduction • response to nutrient • positive regulation of granulocyte differentiation • response to insulin stimulus • regulation of Rac protein signal transduction • positive regulation of catalytic activity • histone H4-K5 acetylation • histone H4-K8 acetylation • histone H4-K16 acetylation • positive regulation of proteolysis • positive regulation of transcription from RNA polymerase II promoter • regulation of insulin receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of histone H3-K4 methylation • cellular response to retinoic acid • histone H3-K4 trimethylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8473 108155 Ensembl ENSG00000147162 ENSMUSG00000034160 UniProt O15294 Q8CGY8 RefSeq (mRNA) NM_003605 NM_139144 RefSeq (protein) NP_858058 NP_631883 Location (UCSC) Chr X:
70.75 – 70.8 Mb Chr X:
101.64 – 101.68 Mb PubMed search

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit is an enzyme that in humans is encoded by the OGT gene.

O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues of intracellular proteins. Since both phosphorylation and O-GlcNAcylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine or 14 tetratricopeptide repeats, depending on the splice variant, and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms (nucleocytoplasmic and mitochondrial) have been found for this gene.