Function
O6-alkyl-guanine is the major carcinogenic lesion in DNA induced by alkylating mutagens. This DNA adduct is removed by the repair protein, O6-methylguanine-DNA methyltransferase. This protein is not a true enzyme since it accepts the alkyl group from the lesion in a stoichiometric reaction and the active enzyme is not regenerated after it is alkylated. The methyl-acceptor residue in the protein is cysteine.
Read more about this topic: O-6-methylguanine-DNA Methyltransferase
Famous quotes containing the word function:
““... The state’s one function is to give.
The bud must bloom till blowsy blown
Its petals loosen and are strown;
And that’s a fate it can’t evade
Unless ‘twould rather wilt than fade.””
—Robert Frost (1874–1963)
“... the function of art is to do more than tell it like it is—it’s to imagine what is possible.”
—bell hooks (b. c. 1955)
“The function of muscle is to pull and not to push, except in the case of the genitals and the tongue.”
—Leonardo Da Vinci (1425–1519)