History
Nitrous oxide as a single gas was first used as a medical analgesic in 1844 by American dentist Horace Wells, growing in popularity in the late 1800s. Negative side effects were found from the hypoxia caused by a lack of oxygen, and the requirement to have at least 21% oxygen content in the gas was discovered (the same percentage as in air).
In 1911, the anaesthetist Arthur Ernest Guedel first described the use of self-administration of a nitrous oxide and oxygen mix.
It was not until 1961 that the first paper was published by Michael Tunstall et al. describing the administration of a pre-mixed 50:50 nitrous oxide and oxygen mix, which led to the commercialisation of the product.
Read more about this topic: Nitrous Oxide And Oxygen
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“Let us not underrate the value of a fact; it will one day flower in a truth. It is astonishing how few facts of importance are added in a century to the natural history of any animal. The natural history of man himself is still being gradually written.”
—Henry David Thoreau (1817–1862)
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—Henry Geldzahler (1935–1994)
“What you don’t understand is that it is possible to be an atheist, it is possible not to know if God exists or why He should, and yet to believe that man does not live in a state of nature but in history, and that history as we know it now began with Christ, it was founded by Him on the Gospels.”
—Boris Pasternak (1890–1960)