Degradation and Elimination
A neurotransmitter must be broken down once it reaches the post-synaptic cell to prevent further excitatory or inhibitory signal transduction. For example, acetylcholine (ACh), an excitatory neurotransmitter, is broken down by acetylcholinesterase (AChE). Choline is taken up and recycled by the pre-synaptic neuron to synthesize more ACh. Other neurotransmitters such as dopamine are able to diffuse away from their targeted synaptic junctions and are eliminated from the body via the kidneys, or destroyed in the liver. Each neurotransmitter has very specific degradation pathways at regulatory points, which may be the target of the body's own regulatory system or recreational drugs.
Read more about this topic: Neurotransmitter
Famous quotes containing the words degradation and, degradation and/or elimination:
“Gradually we come to admit that Shakespeare understands a greater extent and variety of human life than Dante; but that Dante understands deeper degrees of degradation and higher degrees of exaltation.”
—T.S. (Thomas Stearns)
“In her present ignorance, woman’s religion, instead of making her noble and free, by the wrong application of great principles of right and justice, has made her bondage but more certain and lasting, her degradation more hopeless and complete.”
—Elizabeth Cady Stanton (1815–1902)
“To reduce the imagination to a state of slavery—even though it would mean the elimination of what is commonly called happiness—is to betray all sense of absolute justice within oneself. Imagination alone offers me some intimation of what can be.”
—André Breton (1896–1966)