MKE could refer to:
- Milwaukee, Wisconsin
- General Mitchell International Airport in Milwaukee, Wisconsin; IATA airport code MKE.
- Mechanical and Chemical Industry Corporation (Turkey), in Turkish, Makina ve Kimya Endustrisi Kurumu
- Milwaukee Intermodal Station; Amtrak station code MKE.
- MKE (tabloid), a weekly publication in Milwaukee which ended in 2008.
- MKE Ankaragücü, a Turkish football club in Ankara
- MKE Kırıkkalespor, a Turkish football club in Kirikkale
- MSDW Structured Asset Corporation; New York Stock Exchange symbol MKE.