Meyers, a variant surname spelling of Myers, is of both English and German surname origin. The German surname refers to a town magistrate. The English surname may mean "physician" (from "mire", Old French, or "marsh" (from "myrr", Old Norse}. There are many variant spellings. People with the surname include:
- Albert I. Meyers (1932–2007), American organic chemist, professor at Colorado State University
- Ann Meyers (born 1955), former American basketball player and current sportscaster
- Ari Meyers (born 1969), American actress, best known from the television series Kate & Allie
- Brad Meyers (born 1980), Australian National Rugby League player
- Bruce F. Meyers, American car designer and entrepreneur, best known for the Meyers Manx dune buggy
- Charles M. Meyers, park keeper and early designer of Washington Park in Portland, Oregon
- Charley Meyers, one of the founders of Weaver Aircraft Company of Ohio
- Chief Meyers (1880–1971), Major League Baseball catcher from 1909 to 1917
- Dave Meyers, American music video director
- Françoise Meyers, granddaughter of Eugène Schueller and member of the L'Oréal board of directors
- Gerald C. Meyers, American industrialist, former Chairman of American Motors Corporation
- Glenford J. Myers, computer scientist, an author of a number of books.
- Jerry Meyers (born 1965), head baseball coach at Old Dominion University, 2004–present
- Joel Meyers, American sportscaster, current play-by-play announcer for the Los Angeles Lakers
- Jonathan Rhys Meyers (born 1977), Irish actor
- Joseph E. Meyers I (born 1976), American computer programmer and College Instructor
- Josh Meyers (ice hockey) (born 1985), American professional ice hockey player
- Josh Meyers (born 1976), American actor and comedian, cast member of the American sketch comedy show MADtv
- Krystal Meyers (born 1988), American Christian rock musician
- Marilyn Meyers, Chargé d'Affaires ad interim to Burma from September 1994 - October 1996
- Mike Meyers (baseball) (born 1977), Canadian professional baseball player
- Nancy Meyers (born 1949), American film director, producer, and screenwriter
- Scott Meyers, American author of several books on object oriented programming
- Seth Meyers (born 1973), American actor and comedian, cast member of Saturday Night Live
- Sidney Meyers (1906–1969), American film director and editor
- William M. Colmer (middle name, Meyers) (1890–1980), Mississippi politician
- Captain W. J. Meyers (?-1925), captain of the SS Cotopaxi when it sank in 1925
- John Meyers, better known as Johnny Weaver, professional wrestler and wrestling commentator
- Lisa Meyers, wife of Kris Kristofferson
- Nina Palmquist Meyers, wife of Earl Warren
- Richard Meyers (born 1949), better known as Richard Hell, American punk-rock singer, songwriter, and bass guitarist
- Roger Meyers, Sr., fictional founder of Itchy and Scratchy Studios
- William "Billy" Meyers, "policy dealer" (numbers racketeer) investigated by the Lexow Committee in New York, 1894–1895
- William H. Meyers, husband to Countess Marie Larisch von Moennich