Meslier is originally a French surname, and can refer to the following:
- People:
- Jean Meslier (1664–1729), Catholic priest who was discovered after his death to have written a Testament attacking religion.
- Places:
- Meslières, a village and commune in the Doubs département of eastern France.
- Other:
- Petit Meslier, a rare French variety of white wine grape
- Meslier (grape), another name for the Loire Valley grape Meslier-Saint-François
- Meslier vert, another name for Peurion, a traditional French variety of white wine grape
- Meslier is also a synonym for the grape Roublot
- Asteroid 7062 is named after Jean Meslier, see Meanings of asteroid names (7001-7500).