MCF can refer to:
- 1000 cubic feet, a unit of measure in the oil and gas industry for natural gas, more often written Mcf
- MacCentral Forum, an internet forum which focuses on the Apple Macintosh
- Macrophage chemotactic factor
- Magic Circle Festival, a Germany-based Heavy-Metal-Festival
- Magnetic confinement fusion, an approach for thermonuclear fusion
- Malaysia Chess Federation
- Mangalore Chemicals & Fertilizers, a company which produces fertilizers
- Master Control Facility, ISRO's communication satellite control centre
- Marine Commando Force
- Marine Corrosion Forum
- Median Cell Fragility, the concentration of NaCl at which 50% of lysis occurs to a blood sample
- Malignant catarrhal fever
- The marginal cost of funds
- Meta Content Framework
- Methyl chloroform or 1,1,1-trichloroethane
- Micro Colonial Fungi
- Micro-Complement-Fixation Test
- The Migrant Children's Foundation, a non profit organisation based in Beijing, China
- Modulation contrast function, or contrast transfer function (CTF) is term in optical imaging
- Monegasque franc, the former currency of Monaco
- Multimedia Container Format, a predecessor of Matroska multimedia container
- Municipal Crunk Force
- Muskegon Correctional Facility
- Mystery Case Files, a series of PC games developed by Big Fish Studios and distributed by Big Fish Games
- Michael C. Fina
- Most Common Factor