LPE can refer to:
- lambda pi eta, a fraternity
- LAN Peru, a Peruvian airline
- Lapeer (Amtrak station), Michigan, United States; Amtrak station code LPE
- LimeWire Pirate Edition, a peer-to-peer file sharing (P2P) client program
- Lingenfelter Performance Engineering, an American muscle car (mainly Corvette) tuning company founded by John Lingenfelter and located in Decatur, Indiana
- Liquid phase epitaxy
- Low-Pass Equivalent signal
- Lone pair electrons, a Chemistry topic in molecular structures
- London Press Exchange, a British advertising agency 1892-1969
- Lysophosphatidylethanolamine, a class of chemical compounds
lpe can refer to:
- The ISO 639-3 code for Lepki (a language of Indonesia - Irian Jaya)
LPe can refer to:
- Longitude of Periapsis