Function
It is related to many functions via its widespread projections. The LC-NA system modulates cortical, subcortical, cerebellar, brainstem and spinal cord circuits. Some of the most important functions influenced by this system are :
Neuroplasticity
Arousal and sleep-wake cycle
Attention and memory
Emotions
Behavioral flexibility, behavioral inhibition and stress (psychological)
Posture and balance.
The locus coeruleus may figure in clinical depression, panic disorder, and anxiety. Some medications including norepinephrine reuptake inhibitors (reboxetine, atomoxetine), serotonin-norepinephrine reuptake inhibitors (venlafaxine, duloxetine), and norepinephrine-dopamine reuptake inhibitors (bupropion) are believed to show efficacy by acting upon neurons in this area.
Read more about this topic: Locus Coeruleus
Famous quotes containing the word function:
“We are thus able to distinguish thinking as the function which is to a large extent linguistic.”
—Benjamin Lee Whorf (1897–1934)
“To look backward for a while is to refresh the eye, to restore it, and to render it the more fit for its prime function of looking forward.”
—Margaret Fairless Barber (1869–1901)
“The fact remains that the human being in early childhood learns to consider one or the other aspect of bodily function as evil, shameful, or unsafe. There is not a culture which does not use a combination of these devils to develop, by way of counterpoint, its own style of faith, pride, certainty, and initiative.”
—Erik H. Erikson (1904–1994)