Letts may refer to the following people:
- Arthur Letts, English-born millionaire developer of Holmby Hills, Los Angeles, California
- Barry Letts (born 1925), British actor, television director and producer
- David Vanian (born David Letts, 1956), English punk rock musician
- Don Letts (born 1956), British film director and musician
- Goff Letts, Australian politician, as in the First Letts Executive
- John Letts (publisher) (1929–2006), English publisher
- Quentin Letts (born 1963), British journalist
- Tracy Letts (born 1965), American playwright and actor
- Winifred Mary Letts (1882–1972), English-born writer, with Irish connections
Letts may also refer to:
- Letts, known also as Latvians, the indigenous people of Latvia
- Letts nitrile synthesis, chemical reaction
- Letts Filofax Group Ltd, British stationery manufacturer and publisher, best known for diaries and Filofax
- Letts and Lonsdale, British educational publisher
- Letts, Indiana, United States
- Letts, Iowa, United States