Jeffersonian refers to several fields upon which the U.S. President Thomas Jefferson had an impact:
- Jeffersonian architecture
- Jeffersonian democracy
- Jeffersonian Bible
- The Democratic-Republican Party were called Jeffersonians, among many other things
In fiction:
- The Jeffersonian Institute, a fictional research institute in the US television program Bones, based on the real Smithsonian Institution
In transportation:
- Jeffersonian (train), a train operated by the Pennsylvania Railroad