Irritable bowel syndrome (IBS, or spastic colon) is a symptom-based diagnosis characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits. As a functional bowel disorder, IBS has no known organic cause. Diarrhea or constipation may predominate, or they may alternate (classified as IBS-D, IBS-C or IBS-A, respectively). Historically a diagnosis of exclusion, a diagnosis of IBS can now be made on the basis of symptoms alone, in the absence of alarm features such as age of onset greater than 50 years, weight loss, gross hematochezia, systemic signs of infection or colitis, or family history of inflammatory bowel disease. Onset of IBS is more likely to occur after an infection (post-infectious, IBS-PI), a stressful life event, or onset of maturity.
Although there is no cure for IBS, there are treatments that attempt to relieve symptoms, including dietary adjustments, medication and psychological interventions. Patient education and a good doctor-patient relationship are also important.
Several conditions may present as IBS including coeliac disease, fructose malabsorption, mild infections, parasitic infections like giardiasis, several inflammatory bowel diseases, bile acid malabsorption, functional chronic constipation, small intestinal bacterial overgrowth, and chronic functional abdominal pain. In IBS, routine clinical tests yield no abnormalities, although the bowels may be more sensitive to certain stimuli, such as balloon insufflation testing. The exact cause of IBS is unknown. The most common theory is that IBS is a disorder of the interaction between the brain and the gastrointestinal tract, although there may also be abnormalities in the gut flora or the immune system.
IBS has no effect on life expectancy. However, it is a source of chronic pain, fatigue, and other symptoms and contributes to work absenteeism. The high prevalence of IBS and significant effects on quality of life make IBS a disease with a high social cost.
Other articles related to "irritable bowel syndrome, syndrome":
... in this category, 5-HT3 antagonists, have been shown to have this effect, which positively impacts irritable bowel syndrome with diarrhea (IBS-D) ...
... A randomised controlled trial on IBS patients found relaxing an IgG-mediated food intolerance diet led to a 24% greater deterioration in symptoms compared to those on the elimination diet and concluded food elimination based on IgG antibodies may be effective in reducing IBS symptoms and is worthy of further biomedical research ... Further information NIH funding of IBS Research The National Institutes of Health provides a searchable database for grant awards since 1974 on its CRISP database, and provides dollar amounts for recent awards on its Intramural Grant Award Page ...
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List of NIH Funded Research Projects Referring to 'Irritable Bowel' for 2006 Project Number Project Title Dollars Awarded Institution State 5R24DK067674-03 Gastrointestinal Biopsychosocial Research Center 854,134 University of North Carolina NC 3R24DK067674-03S1 Gastrointestinal Biopsychosocial Research Center 146,292 University of North Carolina NC 1K23DK073451-01 Central and Peripheral Autonomic Responses in IBS 125,010 UCLA CA 5K24DK002638-08 Alpha 2 Adrenergic Control in Irritable Bowel Syndrome 139,598 MAYO CLINIC MN 1R21AT003619-01 Mindfulness for Irritable Bowel Syndrome 219,000 University of North Carolina NC 5R01AT001414-04 Enhancing the Placebo Effect in Irritable Bowel Syndrome 642,916 Harvard MA 5R01NR007768-05 Treatment of Fear and Pain in Irritable Bowel Syndrome 299,479 BRENTWOOD CA 5K23DK066271-03 Genetic epidemiology of irritable bowel syndrome (IBS) 126,900 MAYO CLINIC MN 5R21AT002564-02 Patient Variables and Placebo Responses in IBS 193,460 MASSACHESSES GENERAL HOSPITAL MA 5R21DK069628-02 Cross-sensitization between the bladder and colon 144,131 VIRGINIA COMMONWEALTH UNIVERSITY VA 5U19AT003266-02 Functional Bowel Disorders in Chinese Medicine 1,007,873 UNIVERSITY OF MARYLAND MD 5R21DK071767-02 Regulation of spinal NK1R expression by chronic stress 153,798 BRENTWOOD CA 5R01DK054681-07 Alpha-2 Adrenergic Control of Colonic Function in IBS 235,240 MAYO CLINIC MN 2R01NR001094-17A2 A Nursing Study of Gut Function in Menstruating Women 522,661 UNIVERSITY OF WASHINGTON WA 5R03NR009410-02 Autonomic nervous system and visceral hypersensitivity 74,019 UNIVERSITY OF WASHINGTON WA 1K08DK071626-01A1 Effective connectivity of central response to IBS 121,538 UNIVERSITY OF CALIFORNIA CA 5K23NS043435-05 Spatial and Temporal Characteristics of Central Pain Se 164,990 UNIVERSITY OF FLORIDA FL 5P50DK064539-05 Women's Health and Functional Visceral Disorders Center 1,133,615 UCLA CA 5R21DK068155-02 CRF2 Receptor Modulation of Colonic Response to Stress 184,559 UCLA CA 5R01DK066658-04 Neurogenic Pathogenesis of Interstitial Cystitis 305,824 UNIVERSITY OF PITTSBURGH PA 1F31DK074378-01A1 Minority Predoctoral Fellowship Program 26,728 PONCE SCHOOL OF MEDICINE PR 5R01NR005337-05 Recurrent Abdominal Pain in Children 443,225 BAYLOR COLLEGE TX 5R01DK062768-02 Effects of Short Chain Fatty Acids on Colonic Motility 227,581 DUKE NC 5R01NS037424-07 Neurochemical Mechanisms of Visceral Pain 344,400 UNIVERSITY OF MD MD 5R01NS053090-02 Mechanisms of Central and Peripheral Hyperalgesia 328,562 UNIVERSITY OF FLORIDA FL 5R01NS044222-03 Medial Pain Inputs to Monkey Anterior Cingulate Cortex 274,593 UPSTATE MEDICAL UNIVERSITY NY 5R01DK064880-04 A Case Control Study of Interstitial Cystitis 524,437 UNIVERSITY OF MD MD 5K08DK060468-04 GDNF in the Enteric Nervous System 130,113 OHIO STATE UNIVERSITY OH 1R15GM073620-01A1 STRUCTURE FUNCTION STUDY OF MT3 TOXIN 185,220 UNIVERSITE CENTRAL PR 5K24AT000057-08 Individual Differences in CAM Patient-Centered Outcomes 156,399 UNIVERSITY OF AZ AZ 2R01AR046122-06A1 Neuroendocrine Alterations in Fibromyalgia and IBS 277,200 UCLA CA 5F32DK071430-02 Bacterial regulation of GI tract cell proliferation 48,796 UNIVERSITY OF OREGON OR 5R01NS050758-02 Characterization and Plasticity of Visceral Nociceptors 328,232 UNIVERSITY OF PITTSBURGH PA 5R03DE015814-02 Central role of JNK/Jun cascade in visceral nociception 73,726 UNIVERSITY OF TEXAS TX 5R01NS019912-25 Mechanisms and Modulation of Visceral Pain 369,355 UNIVERSITY OF PITTBURGH PA 5P50AR049555-05 ORWH SCOR on Sex and Gender Factors Affecting Women's * 1,073,218 UNIVERSITY OF MD MD 5R01NR004142-09 Nursing Management of IBS Improving Outcomes 595,794 UNIVERSITY OF WASHINGTON WA 2R01DK057038-06A2 RET Ligand Regulation of Intestinal Motility 250,100 WASHINGTON UNIVERSITY MO 5R01DK064592-04 Neuronal control of intestinal motility in mutant mice 488,250 WASHINGTON UNIVERSITY MO 5R01DK047700-11 Regulation of immunosuppressive molecules in IBD 213,944 UNIVERSITY OF NORTH CAROLINA NC 1R01DA019824-01A1 Role of cannabinoid 2 receptors in B lymphocyte function 290,000 UNIVERSITY OF SOUTH FLORIDA FL 1R01NS051466-01A1 ACC Sensitization in Visceral Hypersensitive Rats 342,029 UNIVERSITY OF MICHIGAN MI 2R01DK058173-06A1 Peripheral NMDA Receptors in Visceral Nociception 305,553 UCLA CA 1R21AT003221-01A1 Physiologic Characteristics of Traditional Chinese Medicine Based IBS Subgroups 193,125 UCLA CA 5R21DK069933-02 Oxalobacter as a therapy in IBD-associated urolithiasis 213,121 UNIVERSITY OF FLORIDA FL 5R01DK056762-06 Role of IL-18 in Crohn's Disease (CD) 292,921 UNIVERSITY OF VIRGINIA VA 5R01MH072908-02 Stress Allostasis CRF, Serotonin and the BNST 310,936 EMORY UNIVERSITY GA 5R01DK041004-17 Cholecystokinin—Role in Postprandial Gastric Motility 293,069 UC/DAVIS CA 1K23DK075621-01 The Role of Intestinal Inflammation in the Pathophysiology of IBS 157,184 UNIVERSITY OF NORTH CAROLINA NC 5R01AT001424-04 BRAIN IMAGING AND PAIN ANALYSIS OF PLACEBO ANALGESIA 308,305 UNIVERSITY OF FLORIDA FL 5P30DK034987-21 CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE 998,793 UNIVERSITY OF NORTH CAROLINA NC 5R01NS038767-06 Mechanism of Pain in Patients with Fibromyalgia Syndrome 324,863 UNIVERSITY OF FLORIDA FL 5R01DK033061-22 Corticotropin-releasing Factor-action on GI Function 271,071 UCLA LA 1R21AA016701-01 Mast cells, antidepressants and chronic fatigue syndrome 275,906 TUFFTS MA 5R01DK038327-19 Substance P the Regulation of Intestinal Inflammation 340,541 NEW ENGLAND MEDICAL CTR MA 5R01DK031369-19 Psychophysiology of Irritable Bowel Synbdrome 423,409 UNIVERSITY OF NORT CAROLINA NC 5R01DK068258-03 PURINERGIC NEUROGENIC MUCOSAL SECRETION 291,974 OHIO STATE UNIVERSITY OH Total 18,787,710. ...
... It is being developed for the treatment of overactive bladder and irritable bowel syndrome ... mechanism compared to older established drug treatments for overactive bladder syndrome such as the anticholinergic agents ... Mirabegron is not licensed for irritable bowel syndrome ...
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