Interleukin 29

Identifiers Symbols IFNL1; IL-29; IL29 External IDs OMIM: 607403 HomoloGene: 131189 GeneCards: IFNL1 Gene

Gene Ontology
Molecular function	• receptor binding • cytokine activity • interleukin-28 receptor binding
Cellular component	• extracellular region • extracellular space • interleukin-28 receptor complex
Biological process	• negative regulation of type 2 immune response • negative regulation of cell proliferation • negative regulation of interleukin-13 production • negative regulation of interleukin-5 production • positive regulation of interferon-gamma production • positive regulation of tyrosine phosphorylation of STAT protein • negative regulation of memory T cell differentiation • positive regulation of MHC class I biosynthetic process • negative regulation of T cell differentiation • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of JAK-STAT cascade • positive regulation of immune response • defense response to virus
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 282618 n/a Ensembl ENSG00000182393 n/a UniProt Q8IU54 n/a RefSeq (mRNA) NM_172140.1 n/a RefSeq (protein) NP_742152.1 n/a Location (UCSC) Chr 19:
39.79 – 39.79 Mb n/a PubMed search n/a

Interleukin-29 (IL-29) is a protein that in humans is encoded by the IL29 gene that resides on chromosome 19.

IL-29 is a member of the helical cytokine family and is a type III interferon. It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses.