Comparison With Other Antidepressants
The potency (affinity) of imipramine and other antidepressants on various transporters and receptors are summarized below. Data are from "Pharmacology of antidepressant", Mayo Clin Proc, May 2001, Vol 76.
Potency (affinity) data are expressed as the inverse of equilibrium dissociation constant multiplied by a factor of 10−7. So, the higher the number, the higher the blocking power.
| Drug | SERT | NET | DAT | α1 blockade | D2 blockade | H1 blockade | muscarinic blockade | 5HT2 blockade |
|---|---|---|---|---|---|---|---|---|
| imipramine | 70 | 2.7 | 0.012 | 1.5 | 0.05 | 9.1 | 1.1 | 1.2 |
| desipramine (also an imipramine metabolite) | 5.7 | 128 | 0.024 | 0.77 | 0.03 | 0.91 | 0.5 | 0.38 |
| amitriptyline | 23 | 2.9 | 0.023 | 3.7 | 0.1 | 91 | 5.6 | 3.4 |
| clomipramine | 360 | 2.7 | 0.045 | 2.6 | 0.53 | 3.2 | 2.7 | 3.7 |
| paroxetine | 800 | 2.5 | 0.2 | 0.025 | 0.003 | 0.03 | 0.93 | 0.005 |
| citalopram | 98 | 0.035 | 0.0038 | 0.053 | 0 | 0.21 | 0.045 | 0.34 |
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