Comparison With Other Antidepressants
The potency (affinity) of imipramine and other antidepressants on various transporters and receptors are summarized below. Data are from "Pharmacology of antidepressant", Mayo Clin Proc, May 2001, Vol 76.
Potency (affinity) data are expressed as the inverse of equilibrium dissociation constant multiplied by a factor of 10−7. So, the higher the number, the higher the blocking power.
| Drug | SERT | NET | DAT | α1 blockade | D2 blockade | H1 blockade | muscarinic blockade | 5HT2 blockade |
|---|---|---|---|---|---|---|---|---|
| imipramine | 70 | 2.7 | 0.012 | 1.5 | 0.05 | 9.1 | 1.1 | 1.2 |
| desipramine (also an imipramine metabolite) | 5.7 | 128 | 0.024 | 0.77 | 0.03 | 0.91 | 0.5 | 0.38 |
| amitriptyline | 23 | 2.9 | 0.023 | 3.7 | 0.1 | 91 | 5.6 | 3.4 |
| clomipramine | 360 | 2.7 | 0.045 | 2.6 | 0.53 | 3.2 | 2.7 | 3.7 |
| paroxetine | 800 | 2.5 | 0.2 | 0.025 | 0.003 | 0.03 | 0.93 | 0.005 |
| citalopram | 98 | 0.035 | 0.0038 | 0.053 | 0 | 0.21 | 0.045 | 0.34 |
Read more about this topic: Imipramine
Famous quotes containing the words comparison with and/or comparison:
“Certainly there is not the fight recorded in Concord history, at least, if in the history of America, that will bear a moment’s comparison with this, whether for the numbers engaged in it, or for the patriotism and heroism displayed.”
—Henry David Thoreau (1817–1862)
“Intolerance respecting other people’s religion is toleration itself in comparison with intolerance respecting other people’s art.”
—Wallace Stevens (1879–1955)