Icos

Icos Corporation (trademark ICOS) was the largest biotechnology company in the U.S. state of Washington before it was sold to Eli Lilly and Company in 2007. It was founded in 1989 by David Blech, Isaac Blech, Robert Nowinski, and George Rathmann, a pioneer in the industry and Chief Executive Officer (CEO) and co-founder of Amgen, Icos focused on the development of drugs to treat inflammatory disorders. During its 17-year history, the company conducted clinical trials of twelve drugs, three of which reached the last phase of clinical trials. Icos also manufactured antibodies for other biotechnology companies.

Icos is famous for tadalafil (Cialis), a drug used to treat erectile dysfunction. This drug was discovered by GlaxoSmithKline, developed by Icos, and manufactured and marketed in partnership with Eli Lilly. Boosted by a unique advertising campaign led by the Grey Worldwide Agency, sales from Cialis allowed Icos to become profitable in 2006. Cialis was the only drug developed by the company to be approved. LeukArrest, a drug to treat shock, and Pafase, developed for sepsis, were both tested in phase III clinical trials, but testing was discontinued after unpromising results during the trials. Eli Lilly acquired Icos in January 2007, and most of Icos's workers were laid off soon after. CMC Biopharmaceuticals, a Danish contract manufacturer, bought the remnants of Icos and retained the remaining employees.

Read more about Icos:  History, Acquisition By Eli Lilly

Other articles related to "icos":

Integrated Carbon Observation System - Expected Impacts
... ICOS seeks to meet the data needs of carbon cycle and climate researchers as well as those of politicians and the general public ... ICOS will serve as the backbone to users engaged in developing data assimilation models of greenhouse gas sources and sinks, namely reverse modelling, which allows the deduction of surface carbon ... the Carbon Portal put into place by ICOS, will provide free access to ICOS data, as well as to links with inventory data, and outreach material ...
Follicular B Helper T Cells - Role of ICOS
... The Inducible T-cell co-stimulator (CD278 or ICOS) has proven to provide a particularly critical signal for TFH cells since mice deficient in ICOS are unable to ... However, it was shown that ICOS induces the secretion of IL-21 by activated CD4+ T cells and that IL-21 plays a crucial role in the development of TFH ...
Laser Absorption Spectrometry - Cavity Enhanced Absorption Spectrometry - Integrated Cavity Output Spectroscopy
... Integrated cavity output spectroscopy (ICOS) sometimes called as cavity-enhanced absorption spectroscopy (CEAS) records the integrated intensity behind one of the cavity ... Off-axis ICOS (OA-ICOS) improves on this by coupling the laser light into the cavity from an angle with respect to the main axis so as do not interact with a high density of transverse modes ... Although intensity fluctuations are lower than direct on-axis ICOS, the technique is, however, still limited by a low transmission and intensity fluctuations due to partly excitation ...
Icos - Acquisition By Eli Lilly - Controversy
... In addition to the layoff of Icos employees, other aspects of the acquisition were equally controversial, such as assertions that Icos was being sold too cheaply and that conflicts of interest existed ... The latter related to Icos senior executives, who – despite poor stock performance, in part from failed clinical development programs and an inability to successfully ... Senior executives at Icos received cash payments worth a combined $67.8 million for selling the company to Eli Lilly ...
ICOS (disambiguation)
... ICOS was the largest biotechnology company in the U.S ... ICOS may also refer to The International Code of Maritime Signals Integrated Carbon Observation System The International Council on Security and Development (ICOS) International Council of Onomastic Sciences ...