Humphries is a surname, and may refer to:
- Barry Humphries (born 1934), Dame Edna Average, Australian Comedian
- Carla Humphries (born 1988), aka Carla Loren, model and actress
- Charles Humphries, British countertenor
- Chris Humphries (1947–2009), British botanist
- David Humphries (born 1953), English cricketer, brother of Mark Humphries
- Edward "Ted" Humphries, Australian politician
- Gary Humphries (born 1958), Australian politician
- Gemma Humphries, British weather forecaster
- Gerald Humphries (1908–1983), English cricketer
- Guy Humphries (1923–2010), Louisiana judge
- Henry Humphries (1879–1964), Canadian cricketer
- Jay Humphries (born 1962), American basketball player
- Joe Humphries (1876–1946), English cricketer
- John Humphries (disambiguation), several people
- Kris Humphries (born 1985), American basketball player
- Les Humphries of the Les Humphries Singers
- Lex Humphries (1936–1994), jazz drummer
- Mark Humphries (born 1965), English cricketer, brother of David Humphries
- Ralph "Rusty" Humphries (born 1965), American radio presenter
- Shawn Paul Humphries (1971–2005), American murderer
- Stan Humphries (born 1965), American football player
- Tessa Humphries, Australian actress
- Tom Humphries, Irish sportsjournalist
- Tony Humphries, Administrator of British overseas territory