Symptoms
The classical presentation of primary HHV-6b infection is as exanthema subitum (ES) or "roseola", featuring a high temperature followed by a rash. However a recent study showed that a rash is not a distinguishing feature of HHV-6 infections, with rates similar to non-HHV-6 infections - 10-20% of febrile children in both groups, in one US study. This study recorded HHV-6 infection rates among children attending the hospital with a fever and found that 15% had HHV-6. HHV-6 infections more frequently presented with high temperatures (over 40C), at a rate of around two thirds compared to less than half in the non-HHV-6 patients. Similarly significant differences were seen in malaise and irritability, and in tympanic membrane inflammation.
Most infections occur at an early age. A study conducted in Japan found that, by 13 months of age, almost all children acquire a primary HHV-6 infection.
Primary infection in adults tend to be more severe.
Read more about this topic: Human Herpesvirus 6
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