HRAS

HRAS

Identifiers Symbols HRAS; C-BAS/HAS; C-H-RAS; C-HA-RAS1; CTLO; H-RASIDX; HAMSV; HRAS1; K-RAS; N-RAS; RASH1 External IDs OMIM: 190020 MGI: 96224 HomoloGene: 55890 ChEMBL: 2167 GeneCards: HRAS Gene

Gene Ontology
Molecular function	• GTPase activity • protein binding • GTP binding • protein C-terminus binding
Cellular component	• Golgi membrane • nucleus • cytoplasm • Golgi apparatus • cytosol • plasma membrane • perinuclear region of cytoplasm
Biological process	• MAPK cascade • activation of MAPKK activity • positive regulation of protein phosphorylation • endocytosis • apoptotic process • induction of apoptosis • chemotaxis • cell cycle arrest • signal transduction • cell surface receptor signaling pathway • epidermal growth factor receptor signaling pathway • small GTPase mediated signal transduction • Ras protein signal transduction • synaptic transmission • axon guidance • blood coagulation • cell proliferation • positive regulation of cell proliferation • negative regulation of cell proliferation • insulin receptor signaling pathway • visual learning • fibroblast growth factor receptor signaling pathway • organ morphogenesis • negative regulation of gene expression • actin cytoskeleton organization • positive regulation of cell migration • mitotic cell cycle G1/S transition checkpoint • regulation of synaptic transmission, GABAergic • positive regulation of Rac GTPase activity • negative regulation of Rho GTPase activity • positive regulation of Rac protein signal transduction • social behavior • positive regulation of MAP kinase activity • positive regulation of MAPK cascade • negative regulation of neuron apoptotic process • positive regulation of DNA replication • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • nerve growth factor receptor signaling pathway • regulation of long-term neuronal synaptic plasticity • positive regulation of epithelial cell proliferation • leukocyte migration • striated muscle cell differentiation • positive regulation of ERK1 and ERK2 cascade • positive regulation of wound healing • cellular senescence • positive regulation of ruffle assembly • positive regulation of actin cytoskeleton reorganization • positive regulation of miRNA metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3265 15461 Ensembl ENSG00000174775 ENSMUSG00000025499 UniProt P01112 Q61411 RefSeq (mRNA) NM_001130442.1 NM_001130443.1 RefSeq (protein) NP_001123914.1 NP_001123915.1 Location (UCSC) Chr 11:
0.53 – 0.54 Mb Chr 7:
141.19 – 141.19 Mb PubMed search

GTPase HRas also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene. The HRAS gene is located on the short (p) arm of chromosome 11 at position 15.5, from base pair 522,241 to base pair 525,549.