Higginbotham may refer to:
- Abraham Higginbotham, American screenwriter
- Charles Higginbotham, Cricketer
- Danny Higginbotham, Stoke City Football Club Player
- Don Higginbotham, Historian
- Ernest Higginbotham, Footballer
- Fred Higginbotham, Ice Hockey player
- Grady Higginbotham, college coach of baseball, basketball, and football at Texas Tech
- Harry Higginbotham, Australian footballer
- Henry Higginbotham, Artist
- Irene Higginbotham, songwriter and concert pianist
- J. C. Higginbotham, jazz trombonist
- James Higginbotham, Professor
- Joan Higginbotham, astronaut
- Kallum Higginbotham, Footballer
- Irv Higginbotham, Baseball player
- A. Leon Higginbotham, Jr., United States Appellate Court judge
- Patrick Higginbotham, United States Appellate Court judge
- Scott Higginbotham, Australian Rugby Union player
- Susan Higginbotham, Author
- Higginbotham's, a company of book sellers and publishers in India