Wiley may refer to:
- Wiley, Colorado, a U.S. town
- Wiley-Kaserne, a district of the city of Neu-Ulm, Germany
- Wiley College, a college in Texas founded by Isaac Wiley
- Wiley Rein LLP, a U.S. Law Firm
- John Wiley & Sons, a publishing company specializing in reference books and academic journals
- USS Wiley (DD-597), a U.S. destroyer named after William Wiley
People:
- Wiley (comics), pen name of American newspaper cartoonist David Wiley Miller
- Wiley (rapper), British grime rapper, MC and producer
As a surname:
- Alan Wiley, British football referee
- Alexander Wiley, former U.S. Senator
- Autrey Nell Wiley, American literary critic
- Cliff Wiley, American track and field athlete
- Charles Wiley, American printer and publisher
- D'Extra Wiley, American R&B singer, artist and producer/screenwriter
- Daniel Day Wiley, American Union brevet brigadier general
- Don Craig Wiley, American crystallographer
- Geeshie Wiley, American blues singer of the early 1930s
- Harvey W. Wiley, American chemist
- Isaac Wiley, founder of Wiley College
- Janet Wiley, All-American Girls Professional Baseball League player
- John C. Wiley, American ambassador
- John D. Wiley, Chancellor of UW-Madison
- Kehinde Wiley, American artist
- Laura I. Wiley, American politician
- Lee Wiley, American jazz singer of the 1930s
- Marcellus Wiley, American football player
- Morlon Wiley, American basketball player and coach
- Nathan Wiley, Canadian musician
- Nathaniel Wiley, American illustrator
- H. Orton Wiley, American Nazarene theologian
- Ralph Wiley, American sports journalist
- Richard E. Wiley, American lawyer and former Chairman of the Federal Communications
- Thomas R. Wiley, American Rock and Blues guitarist
- William Wiley, U.S. sailor in the First Barbary War and namesake of the USS Wiley
- William H. Wiley, Representative to United States Congress from New Jersey and Publisher
As a given name:
- Wiley Brooks, a former leading U.S. figure in the breatharian movement
- Wiley Post, the first person to fly solo around the world
- Wiley Scribner, American politician