HFS may stand for:
- Hyperfine structure
- Hereditarily finite set
- Hexafluorosilicic acid
- High Fructose Syrup an intermediate good in the Food industry.
- WHFS (historic), 'HFS was a slang abbreviation for the radio stations with that call sign in the Washington / Baltimore area
- Hemifacial spasm, a neurologic disorder which causes involuntary spasms in one side of the face
- Hospitality Franchise Systems, (HFS) later Cendant
- Haddonfield Friends School, a Quaker school in Haddonfield, NJ
- Hatfield and Stainforth railway station, England; National Rail station code HFS
Read more about HFS: In Computing