HBZ

Identifiers Symbol HBZ External IDs OMIM: 142310 MGI: 96019 HomoloGene: 110705 GeneCards: HBZ Gene

Gene Ontology
Molecular function	• oxygen transporter activity • iron ion binding • oxygen binding • heme binding
Cellular component	• hemoglobin complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • erythrocyte maturation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3050 15126 Ensembl ENSG00000130656 ENSMUSG00000055609 UniProt P02008 P06467 RefSeq (mRNA) NM_005332 NM_010405 RefSeq (protein) NP_005323 NP_034535 Location (UCSC) Chr 16:
0.2 – 0.2 Mb Chr 11:
32.28 – 32.28 Mb PubMed search

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.